Dosage Form: FOR ANIMAL USE ONLY. There were no adverse effects observed in cats that received 5 mg/kg body weight of enrofloxacin. Cats: Enrofloxacin was administered at a daily dosage rate of 5 mg/kg concurrently with anthelmintics (praziquantel, febantel), an insecticide (propoxur) and another antibacterial (ampicillin). Keep these In humans, there is a risk of user photosensitization within a few hours after excessive exposure to quinolones. Such products should be used with caution in cats. Cats: Clinical efficacy was established in dermal infections (wounds and abscesses) associated with susceptible strains of Pasteurella multocida, Staphylococcus aureus, and Staphylococcus epidermidis. The use of fluoroquinolones in cats has been reported to adversely affect the retina. Available for Android and iOS devices. Mydriasis may be an indication of impending or existing retinal changes. Intradiegetically, the narrative turns centrally on accounts of failed projects related to painting. , The display lights up for a few seconds and then shows the remaining battery capacity (RQ1090/ RQ1062/RQ1060 only). 2 | KCA-BT200 Contents Before use 3 Basic Operation of hands-free phoning (Model-A) 4 Before Use Making a call Receiving a call Call waiting During a call Other functions In his fictional masterpiece La Vie mode d'emploi (1978) he pursues an elaborate confrontation on many levels with paintings and painters, whose prestige he recognizes as a rival to writing, which is thus challenged to reassert its primacy. Les instructions détaillées pour l'utilisation figurent dans le Guide de l'utilisateur. Quinolone carboxylic acid derivatives are classified as DNA gyrase inhibitors. It is unlikely that an acute overdose of either compound would result in symptoms more serious than either anorexia or vomiting, but the adverse effects noted above could occur. It is rapidly absorbed from the digestive tract, penetrating into all measured body tissues and fluids (See Table III). Mode d‘emploi type A-10 Page 47 - 68 Manual de instrucciones modelo A-10 Página 69 - 91. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The dose should be continued for at least 2-3 days beyond cessation of clinical signs, to a maximum of 30 days. Send. A report of “Resistant” indicates that the achievable drug concentrations are unlikely to be inhibitory and other therapy should be selected. Microscopic studies have identified lesions of the articular cartilage following 30 day treatments at either 5, 15 or 25 mg/kg in this age group. Daily doses of 125 mg/kg for up to 11 days induced vomition, inappetence, depression, difficult locomotion and death while adult dogs receiving 50 mg/kg/day for 14 days had clinical signs of vomition and inappetence. The dose for dogs and cats may be administered either as a single daily dose or divided into two (2) equal daily doses administered at twelve (12) hour intervals. Enrofloxacin has demonstrated a significant post-antibiotic effect for both Gram-negative and Gram-positive bacteria and is active in both stationary and growth phases of bacterial replication. No incompatibilities with other drugs are known at this time. YouTube Channel. half of the lowest-end single daily dose range for dogs and half the single daily dose for cats) and the data listed in Tables I and II, the following breakpoints are recommended for canine and feline isolates. Distribution in the Body: Enrofloxacin penetrates into all canine and feline tissues and body fluids. MODE D’EMPLOI SAVE THIS MANUAL GUARDE ESTE MANUAL FOR FUTURE REFERENCE WARNING: To reduce the risk of injury, the user must read and ... SP7072 HD06001 HD09001 ESF_HD06001 HD09001.indd 1 7/10/18 2:07 PM. In Windows 10, version 1803, you can switch devices running any S mode edition to the equivalent non-S mode edition one at a time by using the Microsoft Store or Settings. Mode d’emploi_____ FR Manual de instrucciones ___ ES. Dispense tablets in tight containers only. To activate the DUAL mode simply press two voice selectors at the same time (or press one voice selector while holding another). If no improvement is seen within five days, the diagnosis should be reevaluated and a different course of therapy considered. The elimination half-life in dogs is approximately 21/2 - 3 hours at that dose, while in cats it is greater than 4 hours. 1. Développeur: Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 29 Jan 2021) and others. Mode d'emploi du cialis for celebrex cheap No babies assigned cialis du d'emploi mode table 25. Membrane Permeability Changes Associated with DNA Gyrase Inhibitors in Escherichia coli. GB 2 Before operating the unit, please read this manual thoroughly and retain it for future reference. The brown rot fungus Gloeophyllum striatum can degrade the fluoroquinolone enrofloxacin using hydroxyl radicals. Dogs: Administer orally at a rate to provide 5-20 mg/kg (2.27 to 9.07 mg/lb) of body weight. Individuals with a history of hypersensitivity to quinolones should avoid this product. They may also interrupt bacterial membran… When saturation of the absorption process occurs, the plasma concentration of the active moiety will be less than predicted, based on the concept of dose proportionality. The MIC values for enrofloxacin against these isolates are presented in Table I. In September 2005, the FDA withdrew approval of Baytril for use in water to treat flocks of poultry, as this practice was noted to promote the evolution of fluoroquinolone-resistant strains of the bacterium Campylobacter, a human pathogen.[3]. Palatability: Most dogs will consume Baytril® Taste Tabs® Tablets willingly when offered by hand. Send. - b Scene Mode Connecting to Televisions, Computers, and Printers Shooting, Playback, and Setup Menus i T O m. Introduction ii Introduction For Your Safety To prevent damage to your Nikon product or injury to yourself or to others, read the following safety precautions in their entirety before using this equipment. "Mode d'emploi pour le plus beau des mariages" - est le premier Guide 100 % Brestois autour du mariage. Doses of 125 mg/kg for 5 consecutive days to adult cats induced vomition, depression, incoordination and death while those receiving 50 mg/kg for 6 days had clinical signs of vomition, inappetence, incoordination and convulsions, but they returned to normal. Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System (CNS) disorders. Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. The 5 μg enrofloxacin disk should give the following zone diameters and enrofloxacin powder should provide the following MIC values for reference strains. A report of “Intermediate” is a technical buffer and isolates falling into this category should be retested. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria (See Tables I and II). Enrofloxacin is a synthetic chemotherapeutic agent from the class of the quinolone carboxylic acid derivatives. Enrofloxacin is contraindicated in dogs and cats known to be hypersensitive to quinolones. Enrofloxacin is currently approved by the FDA for the treatment of individual pets and domestic animals in the United States. The mechanism of action of these compounds is very complex and not yet fully understood. Alternatively the organism may be successfully treated if the infection is in a body site where drug is physiologically concentrated. The effect on Escherichia coli is the inhibition of DNA synthesis through prevention of DNA supercoiling. 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. Generic Name: enrofloxacin For severe and/or complicated infections, more prolonged therapy, up to 30 days, may be required. However, controlled studies with histological examination of the articular cartilage have not been conducted in the large or giant breeds. They may also interrupt bacterial membrane integrity.1. For use in animals only. The voice indicators of both selected voices will light when the DUAL mode is active. Support - Aerophone AE-10 Mode d'emploi. Dogs & Cats: The duration of treatment should be selected based on clinical evidence. Breakpoint: Based on pharmacokinetic studies of enrofloxacin in dogs and cats after a single oral administration of 2.5 mg enrofloxacin/kg BW (i.e. 100 TABLET, FILM COATED (TABLET) in 1 BOTTLE, 500 TABLET, FILM COATED (TABLET) in 1 BOTTLE, 50 TABLET, FILM COATED (TABLET) in 1 BOTTLE, 250 TABLET, FILM COATED (TABLET) in 1 BOTTLE. Cats: Administer orally at 5 mg/kg (2.27 mg/lb) of body weight. The primary route of excretion is via the urine. This page was last edited on 14 December 2020, at 12:05. TABLE II — MIC Values for Enrofloxacin Against Canine Urinary Pathogens (Diagnostic laboratory isolates, 1985). Cats: Cats in age ranges of 3 to 4 months and 7 to 10 months received daily treatments of 25 mg/kg for 30 consecutive days with no adverse effects upon the clinical chemistry, hematological or histological parameters. Animal Health Division, ©2004 Bayer HealthCare LLC October, 2004. Selection of a dose within the range should be based on clinical experience, the severity of disease, and susceptibility of the pathogen. It is a bactericidal agent. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. Figure 1 - Serum Concentrations of Enrofloxacin Following a Single Oral or Intramuscular Dose at 2.5 mg/kg in Dogs and a Single Oral Dose at 2.5 mg/kg in Cats. Bayer HealthCare LLC Animal Health Division. Dogs: Enrofloxacin has been administered to dogs at a daily dosage rate of 10 mg/kg concurrently with a wide variety of other health products including anthelmintics (praziquantel, febantel, sodium disophenol), insecticides (fenthion, pyrethrins), heartworm preventatives (diethylcarbamazine) and other antibiotics (ampicillin, gentamicin sulfate, penicillin, dihydrostreptomycin). Gastrointestinal: anorexia, diarrhea, vomiting, elevated liver enzymes, Behavioral: depression, lethargy, nervousness. General information 4 2. The susceptibility of organisms to enrofloxacin should be determined using enrofloxacin 5 mcg disks. Tests indicated no effect on circulating microfilariae or adult heartworms (Dirofilaria immitis) when dogs were treated at a daily dosage rate of 15 mg/kg for 30 days. Libreoffice mode d'emploi pdf Four franke mode d'emploi ipad air Panasonic lumix dmc-fx10 mode d'emploi samsung Mode d emploi kenwood V zug mode d'emploi iphone 4s Baxter diffuseur portable mode d'emploi thermomix Mode d'emploi lave vaisselle hotpoint ariston La vie mode d'emploi perec Mode d'emploi velo appartement kettler Danfoss tp75 mode … Enrofloxacin (ENR) is a fluoroquinolone antibiotic sold by the Bayer Corporation under the trade name Baytril. Compounds that contain metal cations (e.g., aluminum, calcium, iron, magnesium) may reduce the absorption of some quinolone-class drugs from the intestinal tract. Oral treatment of 15 to 28 week old growing puppies with daily dosage rates of 25 mg/kg has induced abnormal carriage of the carpal joint and weakness in the hindquarters. Dogs: Two of the 270 (0.7%) dogs treated with Baytril® (brand of enrofloxacin) Tablets at 5.0 mg/kg per day in the clinical field studies exhibited side effects, which were apparently drug-related. Mode d'emploi PRÉCAUTIONS D'USAGE pages 4 à 6 Guide de démarrage rapide pages 9 à 11 Résolution des problèmes pages 18 à 20. Federal law prohibits the extralabel use of this drug in food-producing animals. Death did occur in some dogs when fed 25 times the labeled rate for 11 days, however. Send. Turn on your Brydge 10.5 Go+ (Fn+Del), then press and hold the Bluetooth key for three seconds. It is effective against: The following data represent minimum inhibitory concentration ranges for a few medically significant bacterial pathogens: Enrofloxacin was banned for poultry use in 2005.[4]. WIKA operating instruction pressure transmitter, model A-10 3 EN 11218720.15 07/2018 EN/DE/FR/ES Contents Declarations of conformity can be found online at www.wika.com Contents 1. Single Oral Dose = 2.5 mg/kg (1.13 mg/lb), Gastrointestinal and Cardiopulmonary Systems, We comply with the HONcode standard for trustworthy health information -. et al. Ocular: Mydriasis, retinal degeneration (retinal atrophy, attenuated retinal vessels, and hyperreflective tapeta have been reported), loss of vision. Dogs: Adult dogs receiving enrofloxacin orally at a daily dosage rate of 52 mg/kg for 13 weeks had only isolated incidences of vomition and inappetence. Simple comme bonjour … Elémentaire même :-) Vivez, revivez ! Cats: No drug-related side effects were reported in 124 cats treated with Baytril® (brand of enrofloxacin) Tablets at 5.0 mg/kg per day for 10 days in clinical field studies. Among other things, such compounds lead to the cessation of cell respiration and division. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. For customer service or to obtain product information, including Material Safety Data Sheet, call 1-800-633-3796. The inhibitory activity on 120 isolates of seven canine urinary pathogens was also investigated and is listed in Table II. Concomitant therapy with other drugs that are metabolized in the liver may reduce the clearance rates of the quinolone and the other drug. 4–5 hours in dogs, 6 hours in cats, 1.5 - 4.5 hours in sheep. Dogs receiving 10 times the labeled dosage rate of enrofloxacin for at least 14 days developed only vomiting and anorexia. Post-Approval Experience: The following adverse experiences, although rare, are based on voluntary post-approval adverse drug experience reporting. Significant improvement of clinical signs is observed following drug withdrawal. Enrofloxacin is a synthetic antibacterial agent from the class of the fluoroquinolone carboxylic acid derivatives. Quinolone carboxylic acid derivatives are classified as DNA gyrase inhibitors. Enrofloxacin is partially deethylated by CYP450 into the active metabolite ciprofloxacin, which is also a fluoroquinolone antibiotic. Enrofloxacin (ENR) is a fluoroquinolone antibiotic sold by the Bayer Corporation under the trade name Baytril.Enrofloxacin is currently approved by the FDA for the treatment of individual pets and domestic animals in the United States. Tablets are available in two sizes (22.7 and 68.0 mg enrofloxacin). In cats 7-10 months of age treated daily for 30 consecutive days, 2 of 4 receiving 5 mg/kg, 3 of 4 receiving 15 mg/kg, 2 of 4 receiving 25 mg/kg and 1 of 4 nontreated controls experienced occasional vomition. Cette chaîne vous fournit des informations au sujet des meilleurs instruments électroniques Roland. 10 Circuit Diagram Wired Control Box on pages 62 - 63 2 3 Troubleshooting Ensure all wirings are correct Please refer to on pages 62 - 63 If the robotic arm does not respond to any of the controls check the BATTERY and GND connectorsn Also check if the batteries are correctly inserted Please refer to on page 52 Press the on/off button once to switch off the shaver. Generally, administration of Baytril Tablets should continue for at least 2-3 days beyond cessation of clinical signs. Following an oral dose in dogs of 2.5 mg/kg (1.13 mg/lb), enrofloxacin reached 50% of its maximum serum concentration in 15 minutes and peak serum level was reached in one hour. The categories of reactions are listed in decreasing order of frequency by body system. 509 likes. Do not exceed 5 mg/kg of body weight per day in cats. Design and function 5 Pin. Consult a physician if irritation persists following ocular or dermal exposure. No incompatibilities with other drugs are known at this time. Baytril 10% solution buvable - mode d'emploi. The administration of enrofloxacin at 20 mg/kg body weight or greater caused salivation, vomition, and depression. The site of action is bacterial gyrase, a synthesis promoting enzyme. Clinical signs of difficult ambulation or associated cartilage lesions have not been observed in 29 to 34 week old puppies following daily treatments of 25 mg/kg for 30 consecutive days nor in 2 week old puppies with the same treatment schedule. Windows 10, version 1809, you can switch devices running any S mode edition to the equivalent non-S mode edition one at a time by using the Microsoft Store, Settings , or you can switch … A graph indicating the mean serum levels following a dose of 2.5 mg/kg (1.13 mg/lb) in dogs (oral and intramuscular) and cats (oral) is shown in Figure 1. In rare instances, use of this product in cats has been associated with Retinal Toxicity. Baytril® (brand of enrofloxacin) Antibacterial Tablets are indicated for the management of diseases associated with bacteria susceptible to enrofloxacin. Adult dogs dosed intramuscularly for three treatments at 12.5 mg/kg followed by 57 oral treatments at 12.5 mg/kg, all at 12 hour intervals, did not exhibit either significant clinical signs or effects upon the clinical chemistry, hematological or histological parameters. Record the serial number in the space provided below. Additionally, dosing at 20 mg/kg body weight or greater resulted in mild to severe fundic lesions on ophthalmologic examination (change in color of the fundus, central or generalized retinal degeneration), abnormal electroretinograms (including blindness), and diffuse light microscopic changes in the retina. 3.Type in the PIN on your Brydge 10.5 Go+ and hit Enter. After administration, watch the animal closely to be certain the entire dose has been consumed. Dogs: Based on the studies discussed under the section on Animal Safety Summary, the use of enrofloxacin is contraindicated in small and medium breeds of dogs during the rapid growth phase (between 2 and 8 months of age). In dogs, the absorption and elimination characteristics of the oral formulation are linear (plasma concentrations increase proportionally with dose) when enrofloxacin is administered at up to 11.5 mg/kg, twice daily.2 Approximately 80% of the orally administered dose enters the systemic circulation unchanged. Bayer HealthCare LLC In clinical field trials utilizing a daily oral dose of 5.0 mg/kg, there were no reports of lameness or joint problems in any breed. Tweet. Titulaire du certificat d'inscription: "Bayer Animal Health GmbH", Kaiser-Wilhelm-Allee 10, D-51373 Leverkusen, Allemagne. The Delete key light will flash blue confirming your Brydge is in pairing mode. A report of “Susceptible” indicates that the pathogen is likely to be inhibited by generally achievable plasma levels. Owner’s Record The model and serial numbers are located on the bottom. The site of action is bacterial gyrase, a synthesis promoting enzyme. Dogs: Clinical efficacy was established in dermal infections (wounds and abscesses) associated with susceptible strains of Escherichia coli, Klebsiella pneumoniae, Proteusmirabilis, and Staphylococcus intermedius; respiratory infections (pneumonia, tonsillitis, rhinitis) associated with susceptible strains of Escherichia coli and Staphylococcus aureus; and urinary cystitis associated with susceptible strains of Escherichia coli, Proteus mirabilis, and Staphylococcus aureus. Most strains of these organisms were found to be susceptible to enrofloxacin in vitro but the clinical significance has not been determined for some of the isolates. No effect on cholinesterase values was observed. The lower limit of the dose range in dogs and the daily dose for cats was based on efficacy studies in dogs and cats where enrofloxacin was administered at 2.5 mg/kg twice daily. Mode d'emploi pour le plus beau des mariages. Pharmacokinetic Evaluation of Enrofloxacin Administered Orally to Healthy Dogs. In cats, it can produce sudden onset blindness when administered by injection, as it is retinotoxic. On your Surface Go, select: • Start • Settings • Devices • Bluetooth & other devices 2 MG10XUF Mode d'emploi Explanation of Graphical Symbols Explication des symboles The lightning flash with arrowhead symbol within an equilateral triangle is intended to alert the user to the presence of uninsulated In a study comparing dogs and cats, the peak concentration and the time to peak concentration were not different. 10 ode demploi du ettoyeur ltrasons Informations générales Introduction Précautions d’emploi Ce mode d’emploi doit être utilisé avec les nettoyeurs ultrasons Shesto ltd. Tous les nettoyeurs doivent être manipulés avec soin afin d’assurer une performance maximale. In cats, no oral absorption information is available at other than 2.5 mg/kg, administered orally as a single dose. Libération de forme - Flacons de 100 ml contenant 2,5 ou 5% de la substance active, ainsi que des ampoules à 10%. Quinolone-class drugs have been associated with cartilage erosions in weight-bearing joints and other forms of arthropathy in immature animals of various species. Animals which receive doses in the upper-end of the dose range should be carefully monitored for clinical signs that may include inappetance, depression, and vomition. Specimens for susceptibility testing should be collected prior to the initiation of enrofloxacin therapy. Yamaha Monitor Speaker System Owner's Manual. Select one or more newsletters to continue. View and Download Yamaha NS-10M STUDIO mode d'emploi online. Mode d’emploi Manual de instrucciones S-10, S-11 Pressure transmitter / Druckmessumformer / Transmetteur de pression / Transmisor de presión S-10 Current terms and conditions apply. Among other things, such compounds lead to the cessation of cell respiration and division. Large breeds may be in this phase for up to one year of age and the giant breeds for up to 18 months. Keep out of reach of children. The mechanism of action of these compounds is very complex and not yet fully understood. Saturable absorption and/or elimination processes may occur at greater doses. Walker, R.D. The Dual Mode The DUAL mode makes it possible to play two voices simultaneously across the entire range of the key-board. Safety in breeding or pregnant cats has not been established. Baytril - solution transparente jaune clair, versée dans un récipient stérile brun foncé, emballé dans des boîtes blanches portant toutes les inscriptions nécessaires. Nom international non chimique ou chimique: enrofloxacine. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures. [5], 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, O=C(O)\C3=C\N(c2cc(N1CCN(CC)CC1)c(F)cc2C3=O)C4CC4, InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26), Learn how and when to remove this template message, "Lawmakers' Help for Drug Firm Tests Limits", "Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: identification of metabolites", https://en.wikipedia.org/w/index.php?title=Enrofloxacin&oldid=994167221, Articles needing additional references from November 2016, All articles needing additional references, Chem-molar-mass both hardcoded and calculated, Chemical pages without DrugBank identifier, Drugboxes which contain changes to watched fields, Articles with unsourced statements from August 2016, Creative Commons Attribution-ShareAlike License. Baytril - le plus nouvel antibiotique, appartenant au groupe des fluoroquinalones. Avoid contact with eyes. Stream Conférence Réemploi, Mode D'emploi - 17/10/19 - INSA Strasbourg by Envirobat Grand Est from desktop or your mobile device This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The absorption and elimination characteristics beyond this point are unknown. Dec 1992. The safe use of enrofloxacin has not been established in large and giant breeds during the rapid growth phase. The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. Five to 7 month old cats had no side effects with daily treatments of 15 mg/kg for 30 days, but 2 of 4 animals had articular cartilage lesions when administered 25 mg/kg per day for 30 days. Extrait du mode d'emploi PHILIPS RQ1050. These two cases of vomition were self-limiting. It has antibacterial activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Share. In September 2005, the FDA withdrew approval of Baytril for use in water to treat flocks of poultry, as this practice was noted to promote the … Mode d’emploi Numatic Lithium polymer (Li-Po) Battery Powered Batterie Lithium-Polymère (Li-Po) Numatic NBV 220 (PBT 230) 2 Kit - AST29 601101 601672 601045 601027 ... 10 Use to suck up hot ashes, lighted cigarette ends or flammable gases. Enrofloxacin is bactericidal, with activity against both Gram negative and Gram positive bacteria. Particularly high levels of enrofloxacin are found in urine. The minimum inhibitory concentrations (MICs) were determined for a series of 39 isolates representing 9 genera of bacteria from natural infections in dogs and cats, selected principally because of resistance to one or more of the following antibiotics: ampicillin, cephalothin, colistin, chloramphenicol, erythromycin, gentamicin, kanamycin, penicillin, streptomycin, tetracycline, triple sulfa and sulfa/trimethoprim. Share. In case of dermal contact, wash skin with soap and water. Concentrations of drug equal to or greater than the MIC for many pathogens (See Tables I, II and III) are reached in most tissues by two hours after dosing at 2.5 mg/kg and are maintained for 8-12 hours after dosing. All tablet sizes are double scored for accurate dosing. Pr interval shortens with adult age in weeks to achieve a beneficial yet inexpensive test for describing cardiac anatomy is more likely to include during their caregiving activities may be seen passing laterally right of the miscarriage, the excessive heart rate has fallen from 34. For medical emergencies or to report adverse reactions, call 1-800-422-9874. Alternatively the tablet(s) may be offered in food or hand-administered (pilled) as with other oral tablet medications. Dougherty, T.J. and Saukkonenn, J.J. Aug 1985. The eliminating organs, based on the drug’s body clearance time, can readily remove the drug with no indication that the eliminating mechanisms are saturated. Gastrointestinal: vomiting, anorexia, elevated liver enzymes, diarrhea, Behavioral: depression, lethargy, vocalization, aggression. 2. If excessive accidental exposure occurs, avoid direct sunlight. Illustrations : Lola Goulard Animation : Olivier Bailly-Maistre Musique :… Target animal safety and toxicology were used to establish the upper limit of the dose range for dogs and treatment duration for dogs and cats. A summary of the body fluid/tissue drug levels at 2 to 12 hours after dosing at 2.5 mg/kg is given in Table III. No adverse effects were observed on reproductive parameters when male dogs received 10 consecutive daily treatments of 15 mg/kg/day at 3 intervals (90, 45 and 14 days) prior to breeding or when female dogs received 10 consecutive daily treatments of 15 mg/kg/day at 4 intervals: between 30 and 0 days prior to breeding, early pregnancy (between 10th & 30th days), late pregnancy (between 40th & 60th days), and during lactation (the first 28 days).
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